EEG signals convey important information about brain activity both in healthy and pathological conditions. However, they are inherently noisy, which poses significant challenges for accurate analysis and interpretation. Traditional EEG artifact removal methods, while effective, often require extensive expert intervention. This study presents LSTEEG, a novel LSTM-based autoencoder designed for the detection and correction of artifacts in EEG signals. Leveraging deep learning, particularly LSTM layers, LSTEEG captures non-linear dependencies in sequential EEG data. LSTEEG demonstrates superior performance in both artifact detection and correction tasks compared to other state-of-the-art convolutional autoencoders. Our methodology enhances the interpretability and utility of the autoencoder's latent space, enabling data-driven automated artefact removal in EEG its application in downstream tasks. This research advances the field of efficient and accurate multi-channel EEG preprocessing, and promotes the implementation and usage of automated EEG analysis pipelines for brain health applications.

The neonatal period is the most vulnerable time for the development of seizures. Seizures in the immature brain lead to detrimental consequences, therefore require early diagnosis. The gold-standard for neonatal seizure detection currently relies on continuous video-EEG monitoring; which involves recording multi-channel electroencephalogram (EEG) alongside real-time video monitoring within a neonatal intensive care unit (NICU). However, video-EEG monitoring technology requires clinical expertise and is often limited to technologically advanced and resourceful settings. Cost-effective new techniques could help the medical fraternity make an accurate diagnosis and advocate treatment without delay. In this work, a novel explainable deep learning model to automate the neonatal seizure detection process with a reduced EEG montage is proposed, which employs convolutional nets, graph attention layers, and fully connected layers. Beyond its ability to detect seizures in real-time with a reduced montage, this model offers the unique advantage of real-time interpretability. By evaluating the performance on the Zenodo dataset with 10-fold cross-validation, the presented model achieves an absolute improvement of 8.31% and 42.86% in area under curve (AUC) and recall, respectively.

In this work, we leverage machine learning techniques to identify potential biomarkers of oxygen desaturation during sleep exclusively from electroencephalogram (EEG) signals in pediatric patients with sleep apnea. Development of a machine learning technique which can successfully identify EEG signals from patients with sleep apnea as well as identify latent EEG signals which come from subjects who experience oxygen desaturations but do not themselves occur during oxygen desaturation events would provide a strong step towards developing a brain-based biomarker for sleep apnea in order to aid with easier diagnosis of this disease. We leverage a large corpus of data, and show that machine learning enables us to classify EEG signals as occurring during oxygen desaturations or not occurring during oxygen desaturations with an average 66.8% balanced accuracy. We furthermore investigate the ability of machine learning models to identify subjects who experience oxygen desaturations from EEG data that does not occur during oxygen desaturations. We conclude that there is a potential biomarker for oxygen desaturation in EEG data.

Automatic sleep scoring is essential for the diagnosis and treatment of sleep disorders and enables longitudinal sleep tracking in home environments. Conventionally, learning-based automatic sleep scoring on single-channel electroencephalogram (EEG) is actively studied because obtaining multi-channel signals during sleep is difficult. However, learning representation from raw EEG signals is challenging owing to the following issues: 1) sleep-related EEG patterns occur on different temporal and frequency scales and 2) sleep stages share similar EEG patterns. To address these issues, we propose a deep learning framework named SleePyCo that incorporates 1) a feature pyramid and 2) supervised contrastive learning for automatic sleep scoring. For the feature pyramid, we propose a backbone network named SleePyCo-backbone to consider multiple feature sequences on different temporal and frequency scales. Supervised contrastive learning allows the network to extract class discriminative features by minimizing the distance between intra-class features and simultaneously maximizing that between inter-class features. Comparative analyses on four public datasets demonstrate that SleePyCo consistently outperforms existing frameworks based on single-channel EEG. Extensive ablation experiments show that SleePyCo exhibits enhanced overall performance, with significant improvements in discrimination between the N1 and rapid eye movement (REM) stages.

Recent promises of generative deep learning lately brought interest to its potential uses in neural engineering. In this paper we firstly review recently emerging studies on generating artificial electroencephalography (EEG) signals with deep neural networks. Subsequently, we present our feasibility experiments on generating condition-specific multichannel EEG signals using conditional variational autoencoders. By manipulating real resting-state EEG epochs, we present an approach to synthetically generate time-series multichannel signals that show spectro-temporal EEG patterns which are expected to be observed during distinct motor imagery conditions.

Single-trial classification of event-related potentials in electroencephalogram (EEG) signals is a very important paradigm of brain-computer interface (BCI). Because of individual differences, usually some subject-specific calibration data are required to tailor the classifier for each subject. Transfer learning has been extensively used to reduce such calibration data requirement, by making use of auxiliary data from similar/relevant subjects/tasks. However, all previous research assumes that all auxiliary data have been labeled. This paper considers a more general scenario, in which part of the auxiliary data could be unlabeled. We propose active semi-supervised transfer learning (ASTL) for offline BCI calibration, which integrates active learning, semi-supervised learning, and transfer learning. Using a visual evoked potential oddball task and three different EEG headsets, we demonstrate that ASTL can achieve consistently good performance across subjects and headsets, and it outperforms some state-of-the-art approaches in the literature.

The present study proposes a deep learning model, named DeepSleepNet, for automatic sleep stage scoring based on raw single-channel EEG. Most of the existing methods rely on hand-engineered features which require prior knowledge of sleep analysis. Only a few of them encode the temporal information such as transition rules, which is important for identifying the next sleep stages, into the extracted features. In the proposed model, we utilize Convolutional Neural Networks to extract time-invariant features, and bidirectional-Long Short-Term Memory to learn transition rules among sleep stages automatically from EEG epochs. We implement a two-step training algorithm to train our model efficiently. We evaluated our model using different single-channel EEGs (F4-EOG(Left), Fpz-Cz and Pz-Oz) from two public sleep datasets, that have different properties (e.g., sampling rate) and scoring standards (AASM and R&K). The results showed that our model achieved similar overall accuracy and macro F1-score (MASS: 86.2%-81.7, Sleep-EDF: 82.0%-76.9) compared to the state-of-the-art methods (MASS: 85.9%-80.5, Sleep-EDF: 78.9%-73.7) on both datasets. This demonstrated that, without changing the model architecture and the training algorithm, our model could automatically learn features for sleep stage scoring from different raw single-channel EEGs from different datasets without utilizing any hand-engineered features.